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Título: | A new ionizable chromophore of 1,4-bis(alkylamino)benzo[g]phthalazine which interacts with DNA by intercalation |
Autor: | Pons, Miquel CSIC ORCID; Campayo, Lucrecia; Martínez-Balbás, Marian CSIC ORCID ; Azorín, Ferran CSIC ORCID ; Navarro Torres, Pilar CSIC ; Giralt, Ernest | Fecha de publicación: | 1991 | Editor: | American Chemical Society | Citación: | Journal of Medicinal Chemistry 34(1):82-86 (1991) | Resumen: | The tricyclic heteroaromatic nucleus of 1,4-bis(alkylamino)benzo[g]phthalazine can be protonated at physiological pH, depending on the nature of the side chains. The interaction of the 3-methoxypropyl derivative with calf thymus and closed, circular DNA has been studied with UV-vis spectroscopy and NMR. The effect of drug binding on the topology of closed, circular DNA was determined by topoisomerase-I catalyzed relaxation of the complex followed by gel electrophoresis. The results strongly support intercalative binding and suggest that this series of compounds are promising targets for anticancer activity evaluation. © 1991 American Chemical Society | Versión del editor: | http://dx.doi.org/10.1021/jm00105a014 | URI: | http://hdl.handle.net/10261/124669 | DOI: | 10.1021/jm00105a014 | ISSN: | 0022-2623 |
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