English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124621
Título

Treatment of hypothyroidism with levothyroxine or a combination of levothyroxine plus L-triiodothyronine

AutorEscobar-Morreale, Héctor F.; Botella-Carretero, José I.; Morreale de Escobar, Gabriella
Fecha de publicación2015
EditorElsevier
CitaciónBest Practice and Research in Clinical Endocrinology and Metabolism 29(1): 57-75 (2015)
ResumenAt present, the drug of choice for the treatment of hypothyroidism is levothyroxine sodium, even though the thyroid gland secretes both thyroxine and 30,3,5-triiodothyronine; the latter is the more active of the two at the cellular level because of its higher affinity for the nuclear thyroid hormone receptors. To date, combined levothyroxine plus liothyronine treatment for hypothyroidism has been evaluated in 15 clinical trials in humans. In two studies, combined therapy seemed to have beneficial effects on mood, quality of life, and psychometric performance of patients, compared with levothyroxine alone; in some of these studies, the patients preferred levothyroxine plus liothyronine combinations. This preference should be balanced against the possibility of adverse events resulting from the addition of liothyronine to levothyroxine. Until clear advantages of levothyroxine plus liothyronine are refdemonstrated, the administration of levothyroxine alone should remain the treatment of choice for replacement therapy of hypothyroidism.
URIhttp://hdl.handle.net/10261/124621
DOI10.1016/j.beem.2014.10.004
Identificadoresdoi: 10.1016/j.beem.2014.10.004
issn: 1521-690X
e-issn: 1878-1594
Aparece en las colecciones: (IIBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.