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http://hdl.handle.net/10261/124616
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dc.contributor.author | Murillo-Cuesta, Silvia | - |
dc.contributor.author | Rodriguez-de la Rosa, Lourdes | - |
dc.contributor.author | Contreras, Julio | - |
dc.contributor.author | Celaya, Adelaida M. | - |
dc.contributor.author | Camarero, Guadalupe | - |
dc.contributor.author | Rivera, Teresa | - |
dc.contributor.author | Varela-Nieto, Isabel | - |
dc.date.accessioned | 2015-11-06T11:38:20Z | - |
dc.date.available | 2015-11-06T11:38:20Z | - |
dc.date.issued | 2015 | - |
dc.identifier | doi: 10.3389/fnagi.2015.00032 | - |
dc.identifier | issn: 1663-4365 | - |
dc.identifier.citation | Frontiers in Aging Neuroscience 7: 32 (2015) | - |
dc.identifier.uri | http://hdl.handle.net/10261/124616 | - |
dc.description | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). | - |
dc.description.abstract | Excessive exposure to noise damages the principal cochlear structures leading to hearing impairment. Inflammatory and immune responses are central mechanisms in cochlear defensive response to noise but, if unregulated, they contribute to inner ear damage and hearing loss. Transforming growth factor ß (TGF-ß) is a key regulator of both responses and high levels of this factor have been associated with cochlear injury in hearing loss animal models. To evaluate the potential of targeting TGF-ß as a therapeutic strategy for preventing or ameliorating noise-induced hearing loss, we studied the auditory function, cochlear morphology, gene expression and oxidative stress markers in mice exposed to noise and treated with TGF-ß1 peptidic inhibitors P17 and P144, just before or immediately after noise insult. Our results indicate that systemic administration of both peptides significantly improved both the evolution of hearing thresholds and the degenerative changes induced by noise-exposure in lateral wall structures. Moreover, treatments ameliorated the inflammatory state and redox balance. These therapeutic effects were dose-dependent and more effective if the TGF-ß1 inhibitors were administered prior to inducing the injury. In conclusion, inhibition of TGF-ß1 actions with antagonistic peptides represents a new, promising therapeutic strategy for the prevention and repair of noise-induced cochlear damage. | - |
dc.description.sponsorship | This study was supported by grants from the Ministerio de Ciencia e Innovación (SAF2011-24391), DIGNA Biotech, the 7th Framework Programme projects AFHELO and TARGEAR for IVN and FIS PI 10/00394 for TR. SM-C, LRdR and GC hold contracts from CIBERER (SM, LRdR) and CSIC Junta para la Ampliación de Estudios programs (GC). | - |
dc.publisher | Frontiers Media | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/304900 | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/612261 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Protection | - |
dc.subject | Cochlear injury | - |
dc.subject | Inflammation | - |
dc.subject | Noise-induced hearing loss | - |
dc.subject | TGF-β | - |
dc.title | Transforming growth factor ß1 inhibition protects from noise-induced hearing loss | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3389/fnagi.2015.00032 | - |
dc.relation.publisherversion | http://dx.doi.org/10.3389/fnagi.2015.00032 | - |
dc.date.updated | 2015-11-06T11:38:21Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Centro de Investigación Biomédica en Red Enfermedades Raras (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.pmid | 25852546 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IIBM) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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Transforming growth factor.pdf | 1,63 MB | Adobe PDF | Visualizar/Abrir |
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