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Título

Glycosphingolipids and cell death: one aim, many ways

AutorGarcía-Ruiz, Carmen ; Morales, Albert ; Fernández-Checa, José C.
Palabras claveApoptosis
Autophagy
ER stress
Lysosomal membrane permeabilization
Membrane microdomains
Mitochondria
Necroptosis
Fecha de publicación31-ene-2015
EditorKluwer Academic Publishers
CitaciónApoptosis : an international journal on programmed cell death 20(5): 607-620 (2015)
ResumenGlycosphingolipids (GSLs) are a family of bioactive lipids that in addition to their role in the regulation of structural properties of membrane bilayers have emerged as crucial players in many biological processes and signal transduction pathways. Rather than being uniformly distributed within membrane bilayers, GSLs are localized in selective domains called lipid rafts where many signaling platforms operate. One of the most important functions of GSLs, particularly ceramide, is their ability to regulate cell death pathways and hence cell fate. This complex role is accomplished by the ability of GSLs to act in distinct subcellular strategic centers, such as mitochondria, endoplasmic reticulum (ER) or lysosomes to mediate apoptosis, ER stress, autophagy, lysosomal membrane permeabilization and necroptosis. Hence better understanding the role of GSLs in cell death may be of relevance for a number of pathological processes and diseases, including neurodegeneration, metabolic liver diseases and cancer. © 2015 Springer Science+Business Media
Versión del editorhttp://dx.doi.org/10.1007/s10495-015-1092-6
URIhttp://hdl.handle.net/10261/124601
DOI10.1007/s10495-015-1092-6
Identificadoresdoi: 10.1007/s10495-015-1092-6
issn: 1360-8185
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