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Effect of 2Gly.ZnCl2.2H2O on antioxidant status in rats under fasciolosis

AuthorsGabrashanska, M.; Manga-González, M. Yolanda ; Ermidou-Pollet, S.; Anisimova, M.; Tepavitcharova, S.
Gly.Zn compound
Antioxidant status
Issue Date2008
CitationTrace Elements and Electrolytes 25(4): 199-205 (2008)
AbstractThe aim of our study was to assess the liver antioxidant status (SOD, GPX, vitamins A, C and E, Se, Zn, MDA), body weights and parasite burden in male Wistar rats experimentally infected per os with Fasciola hepatica (25 metaçercariae) and treated with a daily dose of 6 mg 2Gly.ZnCI2.2H20. During the acute (4 weeks) and chronic stage (6 - 10 weeks) of fasciolosis, antioxidant/oxidant imbalance ocçurred. SOD activity, levels of vitamina A, C, E, Zn and Se were reduced whereas the amount of MDA was increased. Body weights were lower in the infected rats during the acute an chronic stages. Application of 2Gly.ZnCl2.2H20 increasad the enzyme activities, the levels of vitamin E and A, Zn and Se, and reduced MDA concentration. Body weights increased but the parasite burden was not changed after treatment. The compound did not shaw antiparasitic action.
Description7 pages, 7 figures.
Publisher version (URL)http://www.dustri.com/nc/journals-in-english/mag/trace-elements-and-electrolytes/vol/volume-25/issue/4th-quarter-5.html
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