1. DIGITAL.CSIC
  2. Biología y Biomedicina
  3. Instituto de Investigaciones Biomédicas de Barcelona (IIBB)
  4. (IIBB) Artículos
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124556
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE

Comparte tu historia
de Acceso Abierto
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorBejaoui, Mohamed-
dc.contributor.authorPantazi, Eirini-
dc.contributor.authorDe Luca, Viviana-
dc.contributor.authorPanisello-Roselló, Arnau-
dc.contributor.authorFolch-Puy, Emma-
dc.contributor.authorHotter, Georgina-
dc.contributor.authorCapasso, Clemente-
dc.contributor.authorSupuran, Claudiu T.-
dc.contributor.authorRoselló-Catafau, Joan-
dc.date.accessioned2015-11-05T12:46:11Z-
dc.date.available2015-11-05T12:46:11Z-
dc.date.issued2015-07-30-
dc.identifierissn: 1932-6203-
dc.identifier.citationPLoS ONE 10(7): e0134499 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/124556-
dc.descriptionCorrection at: Bejaoui M, Pantazi E, De Luca V, Panisello A, Folch-Puy E, et al. (2015) Correction: Carbonic Anhydrase Protects Fatty Liver Grafts against Ischemic Reperfusion Damage. PLoS ONE 10(9): e0139411. doi: 10.1371/journal.pone.0139411-
dc.description.abstract© 2015 Bejaoui et al. Carbonic anhydrases (CAs) are ubiquitous metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate and a proton. CAs are involved in numerous physiological and pathological processes, including acid-base homeostasis, electrolyte balance, oxygen delivery to tissues and nitric oxide generation. Given that these processes are found to be dysregulated during ischemia reperfusion injury (IRI), and taking into account the high vulnerability of steatotic livers to preservation injury, we hypothesized a new role for CA as a pharmacological agent able to protect against ischemic damage. Two different aspects of the role of CA II in fatty liver grafts preservation were evaluated: 1) the effect of its addition to Institut Georges Lopez (IGL-1) storage solution after cold ischemia; 2) and after 24h of cold storage followed by two hours of normothermic ex-vivo perfusion. In all cases, liver injury, CA II protein concentration, CA II mRNA levels and CA II activity were determined. In case of the ex-vivo perfusion, we further assessed liver function (bile production, bromosulfophthalein clearance) and Western blot analysis of phosphorylated adenosine monophosphate activated protein kinase (AMPK), mitogen activated protein kinases family (MAPKs) and endoplasmic reticulum stress (ERS) parameters (GRP78, PERK, IRE, eIF2αand ATF6). We found that CA II was downregulated after cold ischemia. The addition of bovine CA II to IGL-1 preservation solution efficiently protected steatotic liver against cold IRI. In the case of reperfusion, CA II protection was associated with better function, AMPK activation and the prevention of ERS and MAPKs activation. Interestingly, CA II supplementation was not associated with enhanced CO<inf>2</inf> hydration. The results suggest that CA II modulation may be a promising target for fatty liver graft preservation. Copyright:-
dc.description.sponsorshipEP is a fellowship-holder of the >Agència de Gestió d'Ajuts Universitaris i de Recerca> (2012FI_B00382), Generalitat de Catalunya, Barcelona, Catalonia, Spain. This work was supported by the >Fondo de Investigaciones Sanitarias> (PI12/00519)-
dc.publisherPublic Library of Science-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleCarbonic anhydrase protects fatty liver grafts against ischemic reperfusion damage-
dc.typeartículo-
dc.identifier.doi10.1371/journal.pone.0134499-
dc.identifier.doi10.1371/journal.pone.0139411-
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0134499-
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0139411-
dc.date.updated2015-11-05T12:46:11Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderGeneralitat de Catalunya-
dc.contributor.funderInstituto de Salud Carlos III-
dc.relation.csicSí-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002809es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.pmid26225852-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
Aparece en las colecciones: (IIBB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato
Bejaoui-PLoS-ONE-2015-v10-e0134499.pdf8,2 MBAdobe PDFVista previa
Visualizar/Abrir
Show simple item record

CORE Recommender

PubMed Central
Citations

4
checked on 10-abr-2024

SCOPUSTM   
Citations

11
checked on 15-abr-2024

WEB OF SCIENCETM
Citations

9
checked on 27-feb-2024

Page view(s)

343
checked on 23-abr-2024

Download(s)

289
checked on 23-abr-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


Este item está licenciado bajo una Licencia Creative Commons Creative Commons