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Peripheral amyloid levels present gender differences associated with aging in AβPP/PS1 mice

AutorOrdóñez-Gutiérrez, Lara ; Antón Pérez, Marta ; Wandosell, Francisco
Palabras claveAging
Transgenic mice
Peripheral amyloid
Alzheimer’s disease models
Fecha de publicación2015
EditorIOS Press
CitaciónJournal of Alzheimer's Disease 44: 1063-1068 (2015)
ResumenThe accumulation of amyloid-β (Aβ) peptide is one of the major neuropathological hallmarks of Alzheimer's disease (AD). We have analyzed whether the progression of amyloidosis differentially affects males and females along aging in AβPP/PS1 transgenic mice. The levels of peripheral amyloid, Aβ40 and Aβ42, are not modified in either sex until 9 months of age. After that, however, there is an increase in amyloid levels in plasma among females and a decrease among males. These findings could be essential to design gender-specific strategies in other in vivo experiments or even in AD treatments. Supplementary Figure 1. A) Percentage of the cases of AβPP/PS1 transgenic mice (males and females) that show bladder disturbances. In dark affected individuals, in grey no evidence of any disturbance. Image of a healthy bladder (B) and a swollen bladder (C). D) Western blot analysis of some biochemical markers in the mice brains; 6 and 15 months, male, female, transgenic and wild type.
Identificadoresdoi: 10.3233/JAD-141158
issn: 1875-8908
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