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dc.contributor.authorGarcía Mora, Patricia-
dc.contributor.authorFrías, Juana-
dc.contributor.authorPeñas, Elena-
dc.contributor.authorZielinski, Henryk-
dc.contributor.authorGiménez-Bastida, J. A.-
dc.contributor.authorWiczkowski, W.-
dc.contributor.authorZielinska, C.-
dc.contributor.authorMartínez-Villaluenga, Cristina-
dc.date.accessioned2015-11-04T11:22:55Z-
dc.date.available2015-11-04T11:22:55Z-
dc.date.issued2015-10-
dc.identifierissn: 1756-4646-
dc.identifier.citationJournal of Functional Analysis 18(Part A): 319-332 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/124440-
dc.descriptionTítulo en el postprint: Dual release of peptides and phenolics with antioxidant, ACE-inhibitory and antiinflammatory activities from pinto bean (Phaseolus vulgaris L. var. pinto) proteins by subtilisins-
dc.description.abstractProduction of novel functional ingredients from legume proteins is a valuable strategy to boost their food use and intake. Aimed at a better exploitation of the functional properties of pinto bean hydrolysates, the effectiveness of two subtilisins (Alcalase and Savinase) for the simultaneous release of bioactive peptides and phenolics with antioxidant, angiotensin I converting enzyme (ACE) inhibitory and anti-inflammatory activities was investigated. A higher proteolytic efficiency was observed for Alcalase that increased the concentration of small peptides in hydrolysates after 120 min. Savinase improved hydroxycinnamic acids and flavonoid contents in hydrolysates after 90 min due to its higher esterase activity. The most active hydrolysates combined potent free radical scavenging (326¿348 mmol TE/g), ACE inhibitory (IC50 = 0.22¿0.26 mg/mL) and anti-inflammatory (28¿16% inhibition) activities. Peptide characterization of active hydrolysates confirmed the presence of bioactive fragments derived from phaseolin. These results evidence the promising potential of pinto bean hydrolysates as functional ingredients in the design of healthy foods.-
dc.description.sponsorshipThis research was cofunded by the Spanish Ministry of Economy and Competitiveness (MINECO) and the European Union through the projects AGL2010-16310 and AGL2013-43247-R and FEDER programme, respectively. P. Garcia-Mora thanks MINECO for providing a PhD fellowship. E. Peñas thanks the Spanish Ministry of Economy and Competitiveness, CSIC and European Social Fund for “Ramón y Cajal” contract.-
dc.publisherElsevier-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-43247-R-
dc.relation.isversionofPostprint-
dc.rightsopenAccessen_EN
dc.titleSimultaneous release of peptides and phenolics with antioxidant, ACE-inhibitory and anti-inflammatory activities from pinto bean (Phaseolus vulgaris L. var. pinto) proteins by subtilisins-
dc.typeartículo-
dc.identifier.doi10.1016/j.jff.2015.07.010-
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.jff.2015.07.010-
dc.date.updated2015-11-04T11:22:55Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderEuropean Commission-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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