English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124439
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

The sterols isolated from evening primrose oil inhibit human colon adenocarcinoma cell proliferation and induce cell cycle arrest through upregulation of LXR

AutorMontserrat-de la Paz, Sergio ; Fernández-Arche, Ángeles; Bermúdez, B.; García-Giménez, M. D.
Fecha de publicación2015
CitaciónJournal of Functional Foods 12: 64- 69 (2015)
Resumen© 2014 Elsevier Ltd. Evening primrose oil (EPO) is widely used as a dietary supplement from which beneficial effects have been reported in rheumatic and arthritic conditions, atopic dermatitis, psoriasis, premenstrual and menopausal syndrome, and diabetic neuropathy. The aim of this study was to determine whether phytosterols isolated from evening primrose oil (PS-EPO), and its main components β-sitosterol and campesterol, affect proliferation, cell death, and the cell cycle of human colon adenocarcinoma (HT-29) cells. PS-EPO were a potent antiproliferative agents in a dose- and time-dependent manner, with an IC50 of 62.9 μg/mL after 48 h, lower than β-sitosterol and campesterol (79.0 μM and 71.6 μM respectively). Flow cytometry showed that PS-EPO exerted a stimulatory effect on apoptosis and necrosis, increasing the number of cells in G0/G1 phase. PS-EPO produced a significant upregulation in liver X receptor (LXR) gene expression that may be one of the principal mechanisms of the tumor shrinkage by PS-EPO.
Identificadoresdoi: 10.1016/j.jff.2014.11.004
issn: 1756-4646
Aparece en las colecciones: (IG) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Postprint_2015_JFunctFood_V12_P64.pdf260,74 kBAdobe PDFVista previa
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.