English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124425
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

2-deoxy-2-[18F]fluoro-D-mannose positron emission tomography imaging in atherosclerosis

AutorBoscá, Lisardo ; Narula, Jagat
Fecha de publicación2014
EditorNature Publishing Group
CitaciónNature Medicine 20(2): 215-219 (2014)
ResumenProgressive inflammation in atherosclerotic plaques is associated with increasing risk of plaque rupture. Molecular imaging of activated macrophages with 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]FDG) has been proposed for identification of patients at higher risk for acute vascular events. Because mannose is an isomer of glucose that is taken up by macrophages through glucose transporters and because mannose receptors are expressed on a subset of the macrophage population in high-risk plaques, we applied 18 F-labeled mannose (2-deoxy-2-[18 F]fluoro-D-mannose, [ 18 F]FDM) for targeting of plaque inflammation. Here, we describe comparable uptake of [ 18 F]FDM and [18F]FDG in atherosclerotic lesions in a rabbit model; [ 18 F]FDM uptake was proportional to the plaque macrophage population. Our FDM competition studies in cultured cells with 2-deoxy-2-[14C]carbon-D-glucose ([14C]2DG) support at least 35% higher [18F]FDM uptake by macrophages in cell experiments. We also demonstrate that FDM restricts binding of anti-mannose receptor antibody to macrophages by approximately 35% and that mannose receptor targeting may provide an additional avenue for imaging of plaque inflammation.
Descripciónet al.
URIhttp://hdl.handle.net/10261/124425
DOI10.1038/nm.3437
Identificadoresdoi: 10.1038/nm.3437
issn: 1078-8956
e-issn: 1546-170X
Aparece en las colecciones: (IIBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.