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One-carbon cycle alterations induced by Dyrk1a dosage

AuthorsDelabar, Jean M.; Latour, Alizée; Noll, Christophe; Renon, Marjorie; Salameh, Sacha; Paul, Jean Louis; Arbones, Maria L. CSIC ORCID ; Movassat, Jamileh; Janel, Nathalie
KeywordsCystathionine beta synthase
Murine model
Issue Date2014
CitationMolecular Genetics and Metabolism Reports 1: 487-492 (2014)
Abstract© 2014 The Authors. Published by Elsevier Inc. Hyperhomocysteinemia due to cystathionine beta synthase deficiency confers diverse clinical manifestations. It is characterized by elevated plasma homocysteine levels, a common amino acid metabolized by remethylation to methionine or transsulfuration to cysteine.We recently found a relationship between hepaticDyrk1A protein expression, a serine/threonine kinase involved in signal transduction in biological processes, hepatic S-adenosylhomocysteine activity, and plasma homocysteine levels.We aimed to study whether there is also a relationship between Dyrk1a and cystathionine beta synthase activity. We used different murine models carrying altered gene coy numbers for Dyrk1a, and found a decreased cystathionine beta synthase activity in the liver of mice under-expressing Dyrk1a, and an increased in liver of mice over-expressing Dyrk1a. For each model, a positive correlation was found between cystathionine beta synthase activity and Dyrk1a protein expression in the liver of mice, which was confirmed in a non-modified genetic context. The positive correlation found between liver Dyrk1a protein expression and CBS activity in modified and non-modified genetic context strengthens the role of this kinase in one carbon metabolism.
Publisher version (URL)http://dx.doi.org/10.1016/j.ymgmr.2014.11.004
Identifiersdoi: 10.1016/j.ymgmr.2014.11.004
issn: 2214-4269
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