English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124331
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease

AutorLarive, Romain M.; Moriggi, Giulia; Menacho-Márquez, Mauricio ; Cañamero, Marta; Álava, Enrique de ; Alarcón, Balbino ; Dosil, Mercedes ; Bustelo, Xosé R.
Fecha de publicación14-may-2014
EditorNature Publishing Group
CitaciónNature Communications 5: 3881 (2014)
ResumenR-Ras2 is a transforming GTPase that shares downstream effectors with Ras subfamily proteins. However, little information exists about the function of this protein in tumorigenesis and its signalling overlap with classical Ras GTPases. Here we show, by combining loss- and gain-of-function studies in breast cancer cells, mammary epithelial cells and mouse models, that endogenous R-Ras2 has a role in both primary breast tumorigenesis and the late metastatic steps of cancer cells in the lung parenchyma. R-Ras2 drives tumorigenesis in a phosphatidylinostiol-3 kinase (PI3K)-dependent and signalling autonomous manner. By contrast, its prometastatic role requires other priming oncogenic signals and the engagement of several downstream elements. R-Ras2 function is required even in cancer cells exhibiting constitutive activation of classical Ras proteins, indicating that these GTPases are not functionally redundant. Our results also suggest that application of long-term R-Ras2 therapies will result in the development of compensatory mechanisms in breast tumours. © 2014 Macmillan Publishers Limited. All rights reserved.
Versión del editorhttp://dx.doi.org/10.1038/ncomms4881
URIhttp://hdl.handle.net/10261/124331
DOI10.1038/ncomms4881
Identificadoresissn: 2041-1723
Aparece en las colecciones: (CBM) Artículos
(IBMCC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
RomainM_Larive_Contribution oftheR-Ras2.pdf3,03 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.