English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124308

Multitarget ligands and theranostics: Sharpening the medicinal chemistry sword against prion diseases

AutorBongarzone, Salvatore; Staderini, Matteo; Bolognesi, Maria Laura
Palabras clavebivalent ligands
Creutzfeldt-Jakob disease
prion drug discovery
protein misfolding diseases
rare diseases
Fecha de publicaciónjun-2014
EditorFuture Science
CitaciónFuture Medicinal Chemistry 6(9): 1017-1029 (2014)
ResumenPrion diseases (PrDs) are fatal neurodegenerative disorders, for which no effective therapeutic and diagnostic tools exist. The main pathogenic event has been identified as the misfolding of a disease-associated prion protein. Nevertheless, pathogenesis seems to involve an intricate array of concomitant processes. Thus, it may be unlikely that drugs acting on single targets can effectively control PrDs. In addition, diagnosis occurs late in the disease process, by which point it is difficult to determine a successful therapeutic intervention. In this context, multitarget ligands (MTLs) and theranostic ligands (TLs) emerge for their potential to effectively cure and diagnose PrDs. In this review, we discuss the medicinal chemistry challenges of identifying novel MTLs and TLs against PrDs, and envision their impact on prion drug discovery. © 2014 Future Science Ltd.
Versión del editorhttp://dx.doi.org/10.4155/fmc.14.56
Identificadoresdoi: 10.4155/fmc.14.56
issn: 1756-8927
Aparece en las colecciones: (IBMB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.