English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124285
Título

Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases

AutorFernández-Velasco, María ; González-Ramos, Silvia; Boscá, Lisardo
Fecha de publicación2014
EditorBiochemical Society
CitaciónBiochemical Journal 458(2): 187-193 (2014)
ResumenEmerging evidence points to the involvement of specialized cells of the immune system as key drivers in the pathophysiology of cardiovascular diseases.Monocytes are an essential cell component of the innate immune system that rapidly mobilize from the bone marrow to wounded tissues where they differentiate into macrophages or dendritic cells and trigger an immune response. In the healthy heart a limited, but near-constant, number of resident macrophages have been detected; however, this number significantly increases during cardiac damage. Shortly after initial cardiac injury, e.g. myocardial infarction, a large number of macrophages harbouring a pro-inflammatory profile (M1) are rapidly recruited to the cardiac tissue, where they contribute to cardiac remodelling. After this initial period, resolution takes place in the wound, and the infiltrated macrophages display a predominant deactivation/pro-resolution profile (M2), promoting cardiac repair by mediating pro-fibrotic responses. In the present reviewwe focus on the role of the immune cells, particularly in the monocyte/macrophage population, in the progression of themajor cardiac pathologies myocardial infarction and atherosclerosis.
URIhttp://hdl.handle.net/10261/124285
DOI10.1042/BJ20131501
Identificadoresdoi: 10.1042/BJ20131501
issn: 0264-6021
e-issn: 1470-8728
Aparece en las colecciones: (IIBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.