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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124257

Fascin, may the Forked be with you

AutorOkenve-Ramos, Pilar; Llimargas, Marta
Palabras claveActinbundling
Drosophila morphogenesis
FGFR pathway
Parallel actin bundles (PABs)
Tracheal system development
Fecha de publicación31-oct-2014
EditorTaylor & Francis
Landes Bioscience
CitaciónFly 8(3): 157-164 (2014)
Resumen© 2014 Taylor & Francis Group, LLC. The FGFR pathway triggers a wide range of key biological responses. Among others, the Breathless (Btl, Drosophila FGFR1) receptor cascade promotes cell migration during embryonic tracheal system development. However, how the actin cytoskeleton responds to Btl pathway activation to induce cell migration has remained largely unclear. Our recent results shed light into this issue by unveiling a link between the actin-bundling protein Singed (Sn) and the Btl pathway. We showed that the Btl pathway regulates sn, which leads to the stabilization of the actin bundles required for filopodia formation and actin cytoskeleton rearrangement. This regulation contributes to tracheal migration, tracheal branch fusion and tracheal cell elongation. Parallel actin bundles (PABs) are usually cross-linked by more than one actin-bundling protein. Accordingly, we have also shown that sn synergistically interacts with forked (f), another actin crosslinker. In this Extra View we extend f analysis and hypothesize how both actin-bundling proteins may act together to regulate the PABs during tracheal embryonic development. Although both proteins are required for similar tracheal events, we suggest that Sn is essential for actin bundle initiation and stiffening, while F is required for the lengthening and further stabilization of the PABs.
Versión del editorhttp://dx.doi.org/10.4161/fly.34368
Identificadoresdoi: 10.4161/fly.34368
issn: 1933-6942
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