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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124252
Título

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

AutorRachdi, Latif; Kariyawasam, Dulanjalee; Guez, Fanny; Aïello, Virginie; Arbones, Maria L. ; Janel, Nathalie; Delabar, Jean M.; Polak, Michel; Scharfmann, Raphaël
Palabras claveBeta cell
Beta cell
Diabetes
DYRK1A
DYRK1A
p27
Proliferation
Fecha de publicación30-ene-2014
EditorSpringer
CitaciónDiabetologia 57(5): 960-969 (2014)
ResumenAims/hypothesis: Growth factors and nutrients are important regulators of pancreatic beta cell mass and function. However, the signalling pathways by which these factors modulate these processes have not yet been fully elucidated. DYRK1A (also named minibrain/MNB) is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that has been conserved across evolution. A significant amount of data implicates DYRK1A in brain growth and function, as well as in neurodegenerative processes in Alzheimer's disease and Down's syndrome. We investigated here whether DYRK1A would be an attractive candidate for beta cell growth modulation. Methods: To study the role of DYRK1A in beta cell growth, we used Dyrk1a-deficient mice. Results: We show that DYRK1A is expressed in pancreatic islets and provide evidence that changes in Dyrk1a gene dosage in mice strongly modulate glycaemia and circulating insulin levels. Specifically, Dyrk1a-haploinsufficient mice show severe glucose intolerance, reduced beta cell mass and decreased beta cell proliferation. Conclusions/interpretation: Taken together, our data indicate that DYRK1A is a critical kinase for beta cell growth as Dyrk1a-haploinsufficient mice show a diabetic profile. © 2014 Springer-Verlag Berlin Heidelberg.
Versión del editorhttp://dx.doi.org/10.1007/s00125-014-3174-3
URIhttp://hdl.handle.net/10261/124252
DOI10.1007/s00125-014-3174-3
Identificadoresdoi: 10.1007/s00125-014-3174-3
issn: 1432-0428
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