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Title

Shoc2/Sur8 protein regulates neurite outgrowth

AuthorsSánchez-Ruiloba, Lucía; Iglesias, Teresa ; Oliva, José Luis; Rojas, José María
Issue Date2014
PublisherPublic Library of Science
CitationPLoS ONE 9(12): e114837 (2014)
AbstractThe Shoc2 protein has been implicated in the positive regulation of the Ras-ERK pathway by increasing the functional binding interaction between Ras and Raf, leading to increased ERK activity. Here we found that Shoc2 overexpression induced sustained ERK phosphorylation, notably in the case of EGF stimulation, and Shoc2 knockdown inhibited ERK activation. We demonstrate that ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of EGF, a stimulus that induces proliferation rather than differentiation in these cells. Finally, Shoc2 depletion reduces both NGF-induced neurite outgrowth and ERK activation in PC12 cells. Our data indicate that Shoc2 is essential to modulate the Ras-ERK signaling outcome in cell differentiation processes involved in neurite outgrowth.
DescriptionThis is an openaccess article distributed under the terms of the Creative Commons Attribution License.-- et al.
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0114837
URIhttp://hdl.handle.net/10261/124224
DOI10.1371/journal.pone.0114837
Identifiersdoi: 10.1371/journal.pone.0114837
issn: 1932-6203
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