Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/124205
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A role for fascin in preventing filopodia breakage in Drosophila tracheal cells |
Autor: | Okenve-Ramos, Pilar CSIC ORCID; Llimargas, Marta CSIC ORCID | Palabras clave: | Actin-cytoskeleton Buckling Fascin FGF pathway Filopodia Filopodia breakage Migration Tracheal development |
Fecha de publicación: | 31-oct-2014 | Editor: | Taylor & Francis Landes Bioscience |
Citación: | Communicative and Integrative Biology 7(5): 29741 (2014) | Resumen: | © Pilar Okenve-Ramos and Marta Llimargas. Filopodia are long and thin finger-like protrusions essential for cell migration. They are formed by parallel actin bundles tightly packed by cell type and context dependent actin-bundling proteins. Our recent work analyzing the role of Fascin during tracheal development in Drosophila has shown that Singed (the Drosophila Fascin homolog) acts as a molecular link between the Branchless (FGF)/Breathless (FGFR) pathway and the actin cytoskeleton. We have reported that the lack of Singed (Sn) leads to wavy and flaccid filopodia due to the disorganization of the tracheal actin cytoskeleton. Here we describe for the first time filopodia breakage in Drosophila, and show that Fascin plays a role in this event. We propose that actin filaments in sn mutant filopodia buckle under membrane pressure due to lower bending stiffness, eventually undergoing breakage. Both Filopodia buckling and breakage would impair correct cell navigation and migration. | Versión del editor: | http://dx.doi.org/10.4161/cib.29741 | URI: | http://hdl.handle.net/10261/124205 | DOI: | 10.4161/cib.29741 | Identificadores: | doi: 10.4161/cib.29741 issn: 1942-0889 |
Aparece en las colecciones: | (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Okenve-Comm-Inte-Biol-2014-v7-29741.pdf | 760,14 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
1
checked on 11-feb-2024
SCOPUSTM
Citations
2
checked on 15-mar-2024
Page view(s)
281
checked on 18-mar-2024
Download(s)
215
checked on 18-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.