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A role for fascin in preventing filopodia breakage in Drosophila tracheal cells

AuthorsOkenve-Ramos, Pilar; Llimargas, Marta
FGF pathway
Filopodia breakage
Tracheal development
Issue Date31-Oct-2014
PublisherTaylor & Francis
Landes Bioscience
CitationCommunicative and Integrative Biology 7(5): 29741 (2014)
Abstract© Pilar Okenve-Ramos and Marta Llimargas. Filopodia are long and thin finger-like protrusions essential for cell migration. They are formed by parallel actin bundles tightly packed by cell type and context dependent actin-bundling proteins. Our recent work analyzing the role of Fascin during tracheal development in Drosophila has shown that Singed (the Drosophila Fascin homolog) acts as a molecular link between the Branchless (FGF)/Breathless (FGFR) pathway and the actin cytoskeleton. We have reported that the lack of Singed (Sn) leads to wavy and flaccid filopodia due to the disorganization of the tracheal actin cytoskeleton. Here we describe for the first time filopodia breakage in Drosophila, and show that Fascin plays a role in this event. We propose that actin filaments in sn mutant filopodia buckle under membrane pressure due to lower bending stiffness, eventually undergoing breakage. Both Filopodia buckling and breakage would impair correct cell navigation and migration.
Publisher version (URL)http://dx.doi.org/10.4161/cib.29741
Identifiersdoi: 10.4161/cib.29741
issn: 1942-0889
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