English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/124187
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


A new non-canonical pathway of Gαq protein regulating mitochondrial dynamics and bioenergetics

AuthorsBenincá, Cristiane ; Planagumà, Jesús; De Freitas Shuck, Adriana; Acín-Pérez, Rebeca; Muñoz, Juan Pablo; Almeida, Marina Mateus de; Brown, Joan H.; Murphy, Anne N.; Zorzano, Antonio; Enríquez, José Antonio; Aragay, Anna M.
KeywordsHeterotrimeric G proteins
Issue DateMay-2014
CitationCellular Signalling 26(5): 1135-1146 (2014)
AbstractContrary to previous assumptions, G proteins do not permanently reside on the plasma membrane, but are constantly monitoring the cytoplasmic surfaces of the plasma membrane and endomembranes. Here, we report that the Gαq and Gα11 proteins locate at the mitochondria and play a role in a complex signaling pathway that regulates mitochondrial dynamics. Our results provide evidence for the presence of the heteromeric G protein (Gαq/11βγ) at the outer mitochondrial membrane and for Gαq at the inner membrane. Both localizations are necessary to maintain the proper equilibrium between fusion and fission; which is achieved by altering the activity of mitofusin proteins, Drp1, OPA1 and the membrane potential at both the outer and inner mitochondrial membranes. As a result of the absence of Gαq/11, there is a decrease in mitochondrial fusion rates and a decrease in overall respiratory capacity, ATP production and OXPHOS-dependent growth. These findings demonstrate that the presence of Gαq proteins at the mitochondria serves as a physiological function: stabilizing elongated mitochondria and regulating energy production in Drp1 and Opa1 dependent mechanisms. This thereby links organelle dynamics and physiology. © 2014 Elsevier Inc.
Publisher version (URL)http://dx.doi.org/10.1016/j.cellsig.2014.01.009
Identifiersdoi: 10.1016/j.cellsig.2014.01.009
issn: 0898-6568
Appears in Collections:(IBMB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.