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dc.contributor.authorSanz, Carlos-
dc.contributor.authorFerrer-Mayorga, Gemma-
dc.contributor.authorGonzález-Rodríguez, Águeda-
dc.contributor.authorValverde, Ángela M.-
dc.contributor.authorMartín-Duce, Antonio-
dc.contributor.authorVelasco-Martín, Juan P.-
dc.contributor.authorRegadera, Javier-
dc.contributor.authorFernández, Margarita-
dc.contributor.authorAlemany, Susana-
dc.date.accessioned2015-10-29T12:38:41Z-
dc.date.available2015-10-29T12:38:41Z-
dc.date.issued2013-
dc.identifierdoi: 10.1074/jbc.M112.439547-
dc.identifierissn: 0021-9258-
dc.identifiere-issn: 1083-351X-
dc.identifier.citationJournal of Biological Chemistry 288(21): 15342-15351 (2013)-
dc.identifier.urihttp://hdl.handle.net/10261/124127-
dc.description.abstract[Background]: MAP3K8 (Cot/tpl2) activates MKK1/2-Erk1/2 upon stimulation of receptors from the Toll-like/interleukin-1 receptor superfamily. [Results]: Cot/tpl2 plays an essential role in acetaminophen-induced liver injury by modulating the generation of inflammatory signals induced by necrotic cells. [Conclusion]: Sterile inflammatory processes triggered by tissue damage are modulated by Cot/tpl2. [Significance]: Cot/tpl2 contributes to the development of pathologies associated with inflammation triggered by damage-associated molecular patterns.-
dc.description.sponsorshipThis work was supported by Grants SAF 2011-24481 (to S. A.) and SAF 2012-33283 (to A. M. V.) from MINECO (Spain) Comunidad de Madrid S2010/BMD-2423, EFSD/Amylin Programme 2011 (to A. M. V.) and a grant from the Mutua Madrileña (to S. A.).-
dc.publisherAmerican Society for Biochemistry and Molecular Biology-
dc.relationS2010/BMD-2423/MOIR-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleSterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2-
dc.typeartículo-
dc.identifier.doi10.1074/jbc.M112.439547-
dc.relation.publisherversionhttps://doi.org/10.1074/jbc.M112.439547-
dc.date.updated2015-10-29T12:38:41Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderEuropean Foundation for the Study of Diabetes-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderFundación Mutua Madrileña-
dc.contributor.funderComunidad de Madrid-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001648es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008061es_ES
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