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Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2

AuthorsSanz, Carlos ; Ferrer-Mayorga, Gemma ; González-Rodríguez, Águeda; Valverde, Ángela M.; Martín-Duce, Antonio; Velasco-Martín, Juan P.; Regadera, Javier; Fernández, Margarita ; Alemany, Susana
Issue Date2013
PublisherAmerican Society for Biochemistry and Molecular Biology
CitationJournal of Biological Chemistry 288(21): 15342-15351 (2013)
Abstract[Background]: MAP3K8 (Cot/tpl2) activates MKK1/2-Erk1/2 upon stimulation of receptors from the Toll-like/interleukin-1 receptor superfamily. [Results]: Cot/tpl2 plays an essential role in acetaminophen-induced liver injury by modulating the generation of inflammatory signals induced by necrotic cells. [Conclusion]: Sterile inflammatory processes triggered by tissue damage are modulated by Cot/tpl2. [Significance]: Cot/tpl2 contributes to the development of pathologies associated with inflammation triggered by damage-associated molecular patterns.
Publisher version (URL)https://doi.org/10.1074/jbc.M112.439547
Identifiersdoi: 10.1074/jbc.M112.439547
issn: 0021-9258
e-issn: 1083-351X
Appears in Collections:(IIBM) Artículos
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