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http://hdl.handle.net/10261/124116
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Morán, Tomás | - |
dc.contributor.author | Bernués, Jordi | - |
dc.contributor.author | Azorín, Ferran | - |
dc.date.accessioned | 2015-10-29T11:52:49Z | - |
dc.date.available | 2015-10-29T11:52:49Z | - |
dc.date.issued | 2015-09-15 | - |
dc.identifier | doi: 10.1016/j.ydbio.2015.07.011 | - |
dc.identifier | issn: 1095-564X | - |
dc.identifier.citation | Developmental Biology 405(2): 260-268 (2015) | - |
dc.identifier.uri | http://hdl.handle.net/10261/124116 | - |
dc.description.abstract | © 2015 Elsevier Inc. dKDM5/LID regulates transcription of essential developmental genes and, thus, is required for different developmental processes. Here, we report the essential contribution of dKDM5/LID to hematopoiesis in Drosophila. Our results show that dKDM5/LID is abundant in hemocytes and that its depletion induces over-proliferation and differentiation defects of larval hemocytes and disrupts organization of the actin cytoskeleton. We also show that dKDM5/LID regulates expression of key factors of hematopoietic development. In particular, dKDM5/LID depletion up-regulates expression of several transcription factors involved in hemocytes proliferation and differentiation as well as of several small-GTPases that link signaling effectors to actin cytoskeleton formation and dynamics. | - |
dc.description.sponsorship | This work was supported by grants from MICINN (BFU2012-30724) and the Generalitat de Catalunya (SGR2009-1023 and SGR2014-204). This work was carried out within the framework of the “Centre de Referència en Biotecnologia” of the “Generalitat de Catalunya” | - |
dc.publisher | Academic Press | - |
dc.rights | closedAccess | - |
dc.subject | dKDM5/LID | - |
dc.subject | Drosophila hematopoiesis | - |
dc.subject | Hemocytes proliferation | - |
dc.subject | Hemocytes differentiation | - |
dc.subject | Actin cytoskeleton | - |
dc.title | The Drosophila histone demethylase dKDM5/LID regulates hematopoietic development | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.ydbio.2015.07.011 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.ydbio.2015.07.011 | - |
dc.date.updated | 2015-10-29T11:52:49Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Generalitat de Catalunya | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.openairetype | artículo | - |
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