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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124116
Título

The Drosophila histone demethylase dKDM5/LID regulates hematopoietic development

AutorMorán, Tomás; Bernués, Jordi ; Azorín, Ferran
Palabras clavedKDM5/LID
Drosophila hematopoiesis
Hemocytes proliferation
Hemocytes differentiation
Actin cytoskeleton
Fecha de publicación15-sep-2015
EditorAcademic Press
CitaciónDevelopmental Biology 405(2): 260-268 (2015)
Resumen© 2015 Elsevier Inc. dKDM5/LID regulates transcription of essential developmental genes and, thus, is required for different developmental processes. Here, we report the essential contribution of dKDM5/LID to hematopoiesis in Drosophila. Our results show that dKDM5/LID is abundant in hemocytes and that its depletion induces over-proliferation and differentiation defects of larval hemocytes and disrupts organization of the actin cytoskeleton. We also show that dKDM5/LID regulates expression of key factors of hematopoietic development. In particular, dKDM5/LID depletion up-regulates expression of several transcription factors involved in hemocytes proliferation and differentiation as well as of several small-GTPases that link signaling effectors to actin cytoskeleton formation and dynamics.
Versión del editorhttp://dx.doi.org/10.1016/j.ydbio.2015.07.011
URIhttp://hdl.handle.net/10261/124116
DOI10.1016/j.ydbio.2015.07.011
Identificadoresdoi: 10.1016/j.ydbio.2015.07.011
issn: 1095-564X
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