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Progression of liver oncogenesis in the double transgenic mice c-myc/TGFα is not enhanced by cyclooxygenase-2 expression

AuthorsLlorente-Izquierdo, Cristina ; Mayoral, Rafael ; Cucarella, Carme ; Grau, Carlos; Alvarez, María Soledad; Flores, Juana María; García-Palencia, Pilar; Agra, Noelia ; Castro-Sánchez, Luis; Boscá, Lisardo ; Martín-Sanz, Paloma ; Casado, Marta
Issue Date2013
CitationProstaglandins and Other Lipid Mediators 106: 106-115 (2013)
AbstractCyclooxygenase-2 (COX-2) has been associated with cell growth regulation, tissue remodeling and carcinogenesis. Overexpression of COX-2 in hepatocytes constitutes an ideal condition to evaluate the role of prostaglandins (PGs) in liver pathogenesis. The effect of COX-2-dependent PGs in genetic hepatocarcinogenesis has been investigated in triple c-myc/transforming growth factor α (TGF-α) transgenic mice that express human COX-2 in hepatocytes on a B6CBAxCD1xB6DBA2 background. Analysis of the contribution of COX-2-dependent PGs to the development of hepatocarcinogenesis, evaluated in this model, suggested a minor role of COX-2-dependent prostaglandins to liver oncogenesis as indicated by liver histopathology, morphometric analysis and specific markers of tumor progression. This allows concluding that COX-2 is insufficient for modifying the hepatocarcinogenesis course mediated by c-myc/TGF-α.
Identifiersdoi: 10.1016/j.prostaglandins.2013.03.006
issn: 1098-8823
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