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Polymorphisms in HIF-1alpha affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx

AutorHinojar-Gutiérrez, Adolfo; Quintanilla, Miguel ; Cerezo, L.; Gamallo, Carlos
Fecha de publicación2013
EditorSpringer
CitaciónClinical and Translational Oncology 15(5): 358-363 (2013)
Resumen[Background]: HIF-1alpha plays a key role in the development and progression of cancer. Its polymorphic variants C1772T and G1790A have been associated with greater susceptibility to cancer and increased tumor progression. [Methods]: We determined the distribution of these polymorphisms among 121 patients with glottic cancer and 154 healthy volunteers by PCR-RFLP. We also analyzed the relationship between the presence of these polymorphisms and various clinicopathologic variables. [Results]: Advanced tumors (T3-T4) were associated with the TT variant (p = 0.036), which was present in 75 % of T4 tumors (p = 0.008). Among patients with nodal metastasis (N+), 41.7 and 22 % were carrying the TT and GA variants, respectively, compared with 9.4 and 2 % of the patients with no metastasis (N0), (p = 0.006 and p = 0.032). [Conclusions]: The presence of the TT and GA variants were associated with lymph node metastasis, while the presence of the TT variant can be associated with larger tumor size.
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URIhttp://hdl.handle.net/10261/124090
DOI10.1007/s12094-012-0930-z
Identificadoresdoi: 10.1007/s12094-012-0930-z
issn: 1699-048X
e-issn: 1699-3055
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