Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/124073
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Reglero-Real, Natalia | - |
dc.contributor.author | Álvarez-Varela, Adrián | - |
dc.contributor.author | Marcos Ramiro, Beatriz | - |
dc.contributor.author | Fernández Martín, Laura | - |
dc.contributor.author | Sandoval, Pilar | - |
dc.contributor.author | Correas, Isabel | - |
dc.contributor.author | Alonso, Miguel A. | - |
dc.contributor.author | Millán, Jaime | - |
dc.date.accessioned | 2015-10-29T09:30:56Z | - |
dc.date.available | 2015-10-29T09:30:56Z | - |
dc.date.issued | 2014-09-18 | - |
dc.identifier | doi: 10.1016/j.celrep.2014.08.007 | - |
dc.identifier | issn: 2211-1247 | - |
dc.identifier.citation | Cell Reports 8: 1879- 1893 (2014) | - |
dc.identifier.uri | http://hdl.handle.net/10261/124073 | - |
dc.description.abstract | © 2014 The Authors. Loss of apicobasal polarity is a hallmark of epithelial pathologies. Leukocyte infiltration and crosstalk with dysfunctional epithelial barriers are crucial for the inflammatory response. Here, we show that apicobasal architecture regulates the adhesion between hepatic epithelial cells and lymphocytes. Polarized hepatocytes and epithelium from bile ducts segregate the intercellular adhesion molecule 1 (ICAM-1) adhesion receptor onto their apical, microvilli-rich membranes, which are less accessible by circulating immune cells. Upon cell depolarization, hepatic ICAM-1 becomes exposed and increases lymphocyte binding. Polarized hepatic cells prevent ICAM-1 exposure tolymphocytes by redirecting basolateral ICAM-1 to apical domains. Loss of ICAM-1 polarity occurs in human inflammatory liver diseases and can be induced by the inflammatory cytokine tumor necrosis factor alpha (TNF-α). We propose that adhesion receptor polarization is a parenchymal immune checkpoint that allows functional epithelium to hamper leukocyte binding. This contributes to the haptotactic guidance of leukocytes toward neighboring damaged or chronically inflamed epithelial cells that expose their adhesion machinery. | - |
dc.description.sponsorship | Ministerio de Ciencia e Innovación; grant S2010/ BMD-2305 from Comunidad de Madrid; and grant FIS PI10/00101 from the Ministerio Sanidad and Fundación Mutua Madrileña | - |
dc.publisher | Cell Press | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Apicobasal polarity controls lymphocyte adhesion to hepatic epithelial cells | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.celrep.2014.08.007 | - |
dc.date.updated | 2015-10-29T09:30:56Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/3.0/ | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Fundación Mutua Madrileña | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008061 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
JaimeMillan_Apicobasal_Polarity.pdf | 7,6 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
11
checked on 09-abr-2024
WEB OF SCIENCETM
Citations
9
checked on 26-feb-2024
Page view(s)
267
checked on 19-abr-2024
Download(s)
301
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons