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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/124044
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dc.contributor.authorHerrera, Mercedeses_ES
dc.contributor.authorCasal, J. Ignacioes_ES
dc.contributor.authorPeña, Cristinaes_ES
dc.date.issued2013-02-21-
dc.identifier.citationCancer Sci 104 ( 4 ) 437–444 (2013)es_ES
dc.identifier.issn1347-9032-
dc.identifier.urihttp://hdl.handle.net/10261/124044-
dc.description8 p.-4 fig.-4 tab. Herrera, Mercedes et al.es_ES
dc.description.abstractTumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer-associated fibroblasts (CAF) and M2 macrophages, characterized by high expression of different markers, including a-SMA, FSP1 and FAP, or CD163 and DCSIGN, respectively, are involved in the malignancy of different tumors. In the present study, expression of the above markers in CAF and M2 macrophages was analyzed using RT-PCR and immunohistochemistry in the normal mucosa and tumor tissue from a cohort of 289 colorectal cancer patients. Expression of CAF and M2 markers is associated with the clinical outcome of colorectal cancer patients. Moreover, the combination of CAF and M2 markers identifies three groups of patients with clear differences in the progression of the disease. This combined variable could be a decisive factor in the survival of advanced-stage patients. Taken together, these analyses demonstrate the prognostic involvement of interrelationships between DCSIGN, CD163, a-SMA, FSP1 and FAP markers in the survival of colon cancer patients.es_ES
dc.description.sponsorshipThis work has been supported by Fundaci on Cient ıfica AECC, SAF2010-20750, S2010 ⁄BMD-2344, RTICC-RD06 ⁄ 0020 ⁄ 0020, PI12 ⁄ 02037 and Fundaci on Banco Santander. A.G.H. laboratory was supported by RD06 ⁄ 0020 ⁄ 0040. C.P. is the recipient of a Miguel Servet Contract from the Instituto de Salud Carlos III (CP09 ⁄ 00294) and V.G. is the recipient of a Fundaci on Científica AECC fellowship.es_ES
dc.language.isoenges_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.titleCancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patientses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1111/cas.12096-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/ 10.1111/cas.12096es_ES
dc.identifier.e-issn1349-7006-
dc.contributor.funderFundación Científica Asociación Española Contra el Cánceres_ES
dc.contributor.funderFundación Banco Santanderes_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.relation.csicSíes_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002704es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008049es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.pmid23298232-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
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