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Título

Jumonji family histone demethylases in neural development

AutorFueyo, Raquel; García, María Alejandra; Martínez-Balbás, Marian
Palabras claveDevelopmental signals
Histone demethylation
Jumonji family
Neural specification
Neuronal differentiation
Fecha de publicación21-jun-2014
EditorSpringer
CitaciónCell and Tissue Research 359(1): 87-98 (2015)
Resumen© Springer-Verlag Berlin Heidelberg 2014. Central nervous system (CNS) development is driven by coordinated actions of developmental signals and chromatin regulators that precisely regulate gene expression patterns. Histone methylation is a regulatory mechanism that controls transcriptional programs. In the last 10 years, several histone demethylases (HDM) have been identified as important players in neural development, and their implication in cell fate decisions is beginning to be recognized. Identification of the physiological roles of these enzymes and their molecular mechanisms of action will be necessary for completely understanding the process that ultimately generates different neural cells in the CNS. In this review, we provide an overview of the Jumonji family of HDMs involved in neurodevelopment, and we discuss their roles during neural fate establishment and neuronal differentiation.
Versión del editorhttp://dx.doi.org/10.1007/s00441-014-1924-7
URIhttp://hdl.handle.net/10261/123996
DOI10.1007/s00441-014-1924-7
Identificadoresdoi: 10.1007/s00441-014-1924-7
issn: 1432-0878
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