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Role of neuroinflammation in adult neurogenesis and Alzheimer disease: Therapeutic approaches

AuthorsFuster-Matanzo, Almudena ; Llorens-Martín, M. ; Hernández Pérez, Félix ; Ávila, Jesús
Issue Date12-Mar-2013
PublisherHindawi Publishing Corporation
CitationMediators of Inflammation 2013: 260925 (2013)
AbstractNeuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases, and specially, it has been considered as a hallmark of Alzheimer disease, the most common cause of dementia in the elderly nowadays. Furthermore, neuroinflammation has been demonstrated to affect important processes in the brain, such as the formation of new neurons, commonly known as adult neurogenesis. For this, many therapeutic approaches have been developed in order to avoid or mitigate the deleterious effects caused by the chronic activation of the immune response. Considering this, in this paper we revise the relationships between neuroinflammation, Alzheimer disease, and adult neurogenesis, as well as the current therapeutic approaches that have been developed in the field.
Identifiersdoi: 10.1155/2013/260925
issn: 0962-9351
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