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Título

Pattern reorganization occurs independently of cell division during Drosophila wing disc regeneration in situ

AutorDíaz-García, Sandra; Baonza, Antonio
Fecha de publicación6-ago-2013
EditorNational Academy of Sciences (U.S.)
CitaciónPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110(32): 13032- 13037 (2013)
ResumenOne of the most intriguing problems in developmental biology is how an organism can replace missing organs or portions of its body after injury. This capacity, known as regeneration, is conserved across different phyla. The imaginal discs of Drosophila melanogaster provide a particularly well-characterized model for analyzing regeneration. We have developed a unique method to study organ regeneration under physiological conditions using the imaginal discs of Drosophila. Using this method, we revisited different aspects of organ regeneration. The results presented in this report suggest that during the initial stages of regeneration, different processes occur, including wound healing, a temporary loss of markers of cell-fate commitment, and pattern reorganization. We present evidence indicating that all of these processes occur even when cell division has been arrested. Our data also suggested that Wingless is not required during the early stages of disc regeneration.
URIhttp://hdl.handle.net/10261/123962
DOI10.1073/pnas.1220543110
Identificadoresdoi: 10.1073/pnas.1220543110
issn: 0027-8424
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