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http://hdl.handle.net/10261/123924
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dc.contributor.author | Mingot, José Manuel | - |
dc.contributor.author | Vega, Sonia | - |
dc.contributor.author | Cano, Amparo | - |
dc.contributor.author | García del Portillo, Francisco | - |
dc.contributor.author | Nieto, M. Ángela | - |
dc.date.accessioned | 2015-10-27T11:55:10Z | - |
dc.date.available | 2015-10-27T11:55:10Z | - |
dc.date.issued | 2013 | - |
dc.identifier | doi: 10.1016/j.celrep.2013.09.030 | - |
dc.identifier | issn: 2211-1247 | - |
dc.identifier.citation | Cell Reports 5(3): 727-737 (2013) | - |
dc.identifier.uri | http://hdl.handle.net/10261/123924 | - |
dc.description | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License. | - |
dc.description.abstract | Exportin5 mediates the nuclear export of double-stranded RNAs, including pre-microRNAs, adenoviral RNAs, and tRNAs. When tRNAs are aminoacylated, the Exportin5-aminoacyl (aa)-tRNA complex recruits and coexports the translation elongation factor eEF1A. Here, we show that eEF1A binds to Snail transcription factors when bound to their main target, the E-cadherin promoter, facilitating their export to the cytoplasm in association with the aa-tRNA-Exportin5 complex. Snail binds to eEF1A through the SNAG domain, a protein nuclear export signal present in several transcription factor families, and this binding is regulated by phosphorylation. Thus, we describe a nuclear role for eEF1A and provide a mechanism for protein nuclear export that attenuates the activity of SNAG-containing transcription factors. © 2013 The Authors. | - |
dc.description.sponsorship | This work was supported by grants from the Spanish Ministry of Science and Innovation (SAF2010-21143 to A.C.; BFU2008-01042 and CONSOLIDER-INGENIO 2010 CSD2007-00023 to M.A.N.; and CDS2007-00017 to A.C. and M.A.N.’s lab) and the Generalitat Valenciana (Prometeo 2008/049 and PROMETEOII/2013/002 to M.A.N.). | - |
dc.publisher | Elsevier | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | eEF1A mediates the nuclear export of SNAG-containing proteins via the exportin5-aminoacyl-tRNA complex | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.celrep.2013.09.030 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.celrep.2013.09.030 | - |
dc.date.updated | 2015-10-27T11:55:10Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/3.0/ | - |
dc.contributor.funder | Generalitat Valenciana | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003359 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
Aparece en las colecciones: | (IN) Artículos (IIBM) Artículos |
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eEF1A.pdf | 1,5 MB | Adobe PDF | Visualizar/Abrir |
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