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dc.contributor.authorMingot, José Manuel-
dc.contributor.authorVega, Sonia-
dc.contributor.authorCano, Amparo-
dc.contributor.authorPortillo, Francisco-
dc.contributor.authorNieto, M. Ángela-
dc.date.accessioned2015-10-27T11:55:10Z-
dc.date.available2015-10-27T11:55:10Z-
dc.date.issued2013-
dc.identifierdoi: 10.1016/j.celrep.2013.09.030-
dc.identifierissn: 2211-1247-
dc.identifier.citationCell Reports 5(3): 727-737 (2013)-
dc.identifier.urihttp://hdl.handle.net/10261/123924-
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License.-
dc.description.abstractExportin5 mediates the nuclear export of double-stranded RNAs, including pre-microRNAs, adenoviral RNAs, and tRNAs. When tRNAs are aminoacylated, the Exportin5-aminoacyl (aa)-tRNA complex recruits and coexports the translation elongation factor eEF1A. Here, we show that eEF1A binds to Snail transcription factors when bound to their main target, the E-cadherin promoter, facilitating their export to the cytoplasm in association with the aa-tRNA-Exportin5 complex. Snail binds to eEF1A through the SNAG domain, a protein nuclear export signal present in several transcription factor families, and this binding is regulated by phosphorylation. Thus, we describe a nuclear role for eEF1A and provide a mechanism for protein nuclear export that attenuates the activity of SNAG-containing transcription factors. © 2013 The Authors.-
dc.description.sponsorshipThis work was supported by grants from the Spanish Ministry of Science and Innovation (SAF2010-21143 to A.C.; BFU2008-01042 and CONSOLIDER-INGENIO 2010 CSD2007-00023 to M.A.N.; and CDS2007-00017 to A.C. and M.A.N.’s lab) and the Generalitat Valenciana (Prometeo 2008/049 and PROMETEOII/2013/002 to M.A.N.).-
dc.publisherElsevier-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleeEF1A mediates the nuclear export of SNAG-containing proteins via the exportin5-aminoacyl-tRNA complex-
dc.typeartículo-
dc.identifier.doi10.1016/j.celrep.2013.09.030-
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.celrep.2013.09.030-
dc.date.updated2015-10-27T11:55:10Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/3.0/-
dc.contributor.funderGeneralitat Valenciana-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003359es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
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