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Title

eEF1A mediates the nuclear export of SNAG-containing proteins via the exportin5-aminoacyl-tRNA complex

AuthorsMingot, José Manuel; Vega, Sonia; Cano, Amparo ; Portillo, Francisco ; Nieto, M. Ángela
Issue Date2013
PublisherElsevier
CitationCell Reports 5(3): 727-737 (2013)
AbstractExportin5 mediates the nuclear export of double-stranded RNAs, including pre-microRNAs, adenoviral RNAs, and tRNAs. When tRNAs are aminoacylated, the Exportin5-aminoacyl (aa)-tRNA complex recruits and coexports the translation elongation factor eEF1A. Here, we show that eEF1A binds to Snail transcription factors when bound to their main target, the E-cadherin promoter, facilitating their export to the cytoplasm in association with the aa-tRNA-Exportin5 complex. Snail binds to eEF1A through the SNAG domain, a protein nuclear export signal present in several transcription factor families, and this binding is regulated by phosphorylation. Thus, we describe a nuclear role for eEF1A and provide a mechanism for protein nuclear export that attenuates the activity of SNAG-containing transcription factors. © 2013 The Authors.
DescriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License.
Publisher version (URL)http://dx.doi.org/10.1016/j.celrep.2013.09.030
URIhttp://hdl.handle.net/10261/123924
DOI10.1016/j.celrep.2013.09.030
Identifiersdoi: 10.1016/j.celrep.2013.09.030
issn: 2211-1247
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