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| Título: | IL-6 cooperates with peroxisome proliferator-activated receptor-α-ligands to induce liver fatty acid binding protein (LFABP) up-regulation |
Autor: | Romero-Cuevas, Miguel; González-Rodríguez, Águeda CSIC ORCID; Gavito, Ana L.; Valverde, Ángela M. CSIC ORCID ; Rodríguez de Fonseca, Fernando; Baixeras, Elena CSIC ORCID | Palabras clave: | Hepatocyte WY-14,643 Interleukin 6 Oleoylethanolamide (OEA) GW-6471 PPARα LFABP |
Fecha de publicación: | 2013 | Editor: | John Wiley & Sons | Citación: | Liver International 33(7): 1019-1028 (2013) | Resumen: | [Background]: LFABP plays a critical role in the uptake and intracellular transport of fatty acids (FA) and other peroxisome proliferator-activated receptor alpha (PPARα) ligands. PPARα activation by PPARα ligands bound to LFABP results in gene expression of FA oxidation enzymes and de novo LFABP. The cytokine IL-6 is involved in regulating liver lipid oxidation. [Aims]: To study the ability of IL-6 to modulate the expression of the LFABP in hepatocytes. Methods: HepG2 and mouse primary hepatocytes were used to test LFABP mRNA and protein expression after IL-6 and PPARα-ligand treatments. Mice lacking IL-6 and wild-type C57Bl/6 were subjected to a fasting/re-feeding cycle to monitor hepatic LFABP mRNA kinetics after food intake. [Results]: In hepatocyte cultures, IL-6 treatment stimulated a LFABP mRNA sustained expression. Combined treatment of IL-6 plus PPARα ligands further enhanced LFABP gene and protein expression. In contrast, pretreatment with the PPARα-antagonist GW-6471 prevented the up-regulation of LFABP mRNA induced by IL-6 in the late phase of LFABP kinetics. Furthermore, the up-regulation of LFABP mRNA observed in the liver of wild-type mice 8 h after re-feeding was absent in mice lacking IL-6. [Conclusions]: IL-6 induces LFABP kinetics in hepatocytes and is partially dependent on PPARα. The maximum increase in LFABP expression occurs when the stimulation with IL-6 and PPARα-ligands takes place simultaneously. The in vivo results indicate a postprandial regulation of LFABP that correlates with the presence of IL-6. These effects may have important implications in the postprandial increase in FA uptake and intracellular trafficking in the liver. © 2013 John Wiley & Sons A/S. | Descripción: | et al. | URI: | http://hdl.handle.net/10261/123920 | DOI: | 10.1111/liv.12156 | Identificadores: | doi: 10.1111/liv.12156 issn: 1478-3223 e-issn: 1478-3231 |
| Aparece en las colecciones: | (IIBM) Artículos |
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