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Título

Improved drugability of vasoactive intestinal peptide (VIP) by nanotechnology for therapeutic selective targeting and immunomodulation

AutorPozo, David ; López-Enriquez, Soledad; Klippstein, Rebecca
Fecha de publicación4-nov-2012
CitaciónXI International Congress of Neuroimmunology (2012)
ResumenNanotechnology can address key bottlenecks hindering successful bench to bedside translation of recent research in the development of neuropeptide-based drugs. This is the case for vasoactive intestinal peptide (VIP), where sustained interest in its therapeutic applications needs to devise new methodologies to improve its drugability or to convey innovation to diagnostics to identify cells that result from conditions such as carcinoid metastasis in which VPAC receptors are involved. Here we present our results covering the chemical synthesis and functional characterisation of VIP Au/Ag nanoparticles, the protective effects on protease-based degradation, and the specific target to tumor cells or dendritic cells as an approach to cell therapy by using VIP-nanoliposomes.
DescripciónPóster presentado en el XI International Congress of Neuroimmunology (ISNI), celebrado en Boston (USA) del 4 al 8 de noviembre de 2012
URIhttp://hdl.handle.net/10261/123906
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