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Chemical speciation of MeHg<sup>+</sup> and Hg<sup>2+</sup> in aqueous solution and HEK cells nuclei by means of DNA interacting fluorogenic probes

AuthorsDíaz de Greñu, Borja; García-Calvo, José; Cuevas, José V.; García-Herbosa, Gabriel; García, Begoña ; Busto, Natalia; Ibeas, Saturnino; Torroba, Tomás; Torroba, Blanca; Herrera, Antonio ; Pons, Sebastián
Issue Date1-Jul-2015
PublisherRoyal Society of Chemistry (UK)
CitationChemical Science 6(7): 3757-3764 (2015)
Abstract© 2015 Royal Society of Chemistry. Selected new fluorogenic probes that interact in different ways with Hg<sup>2+</sup> and MeHg<sup>+</sup> have been prepared and used for the chemical speciation of both cations in aqueous solution as well as in HEK293 cells. The best selective speciation of Hg<sup>2+</sup> and MeHg<sup>+</sup> has been achieved by in vitro approaches based on fluorogenic probes supported in cultured cells, due to the particular sensitivity of the HEK293 cells to permeation by Hg<sup>2+</sup>, MeHg<sup>+</sup> and the fluorogenic probes. In particular, MeHg<sup>+</sup> was selectively detected in cell nuclei by probe JG45.
Publisher version (URL)http://dx.doi.org/10.1039/c5sc00718f
Identifiersdoi: 10.1039/c5sc00718f
issn: 2041-6539
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