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Title

Characterization of monoclonal gammopathy of undetermined significance by calorimetric analysis of blood serum proteome

AuthorsBarceló, Francisca; Cerdà, Joan J. CSIC ORCID; Gutiérrez, Antonio; Jiménez-Marco, Teresa; Durán, Maria Antònia; Novo, Andrés; Ros, Teresa; Sampol, Antonia; Portugal, José CSIC ORCID
Issue Date20-Mar-2015
PublisherPublic Library of Science
CitationPLoS ONE 10(3):e0120316 (2015)
Abstract© 2015 Barceló et al. Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant proliferative disorder thatmay progress to multiplemyeloma, a malignant plasma cell neoplasia.We evaluated differential scanning calorimetry (DSC) as an experimental tool for differentiating serum samples of MGUS patients from healthy individuals. DSC thermograms can be used for monitoring changes in the serum proteome associated with MGUS. MGUS patients showed great variability in serum thermogram characteristics, which depended on the IgG, IgA or IgM isotypes and/or the κ or λ light chains. Thermogram feature parameters distinguished patients with MGUS from healthy people. Serum samples, named as non-MGUS, were also collected frompatients with subjacent immunological pathologies who were discarded of having MGUS through serum immunofixation. They were used to verify the sensitivity of DSC for discriminating MGUS from related blood dyscrasias. Only some DSC thermogram feature parameters differentiated, to a lesser extent, between MGUS and non-MGUS individuals.We contemplate DSC as a tool for early diagnosis and monitoring of MGUS.
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0120316
URIhttp://hdl.handle.net/10261/123878
DOIhttp://dx.doi.org/10.1371/journal.pone.0120316
Identifiersissn: 1932-6203
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