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A role for E-cadherin in ensuring cohesive migration of a heterogeneous population of non-epithelial cells

AutorCampbell, Kyra; Casanova, Jordi
Fecha de publicación14-ago-2015
EditorNature Publishing Group
CitaciónNature Communications 6: 7998 (2015)
Resumen© 2015 Macmillan Publishers Limited. All rights reserved. Collective cell migration is a key process underlying the morphogenesis of many organs as well as tumour invasion, which very often involves heterogeneous cell populations. Here we investigated how such populations can migrate cohesively in the Drosophila posterior midgut, comprised of epithelial and mesenchymal cells and show a novel role for the epithelial adhesion molecule E-cadherin (E-Cad) in mesenchymal cells. Despite a lack of junctions at the ultrastructure level, reducing E-Cad levels causes mesenchymal cells to detach from one another and from neighbouring epithelial cells; as a result, coordination between the two populations is lost. Moreover, Bazooka and recycling mechanisms are also required for E-Cad accumulation in mesenchymal cells. These results indicate an active role for E-Cad in mediating cohesive and ordered migration of non-epithelial cells, and discount the notion of E-Cad as just an epithelial feature that has to be switched off to enable migration of mesenchymal cells.
Versión del editorhttp://dx.doi.org/10.1038/ncomms8998
URIhttp://hdl.handle.net/10261/123872
DOI10.1038/ncomms8998
Identificadoresdoi: 10.1038/ncomms8998
issn: 2041-1723
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