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Insect glycerol transporters evolved by functional co-option and gene replacement

AutorFinn, Roderick N.; Chauvigné, François ; Stavang, Jon A.; Bellés, Xavier ; Cerdà, Joan
Fecha de publicaciónjul-2015
EditorNature Publishing Group
CitaciónNature Communications 6: 7814 (2015)
ResumenTransmembrane glycerol transport is typically facilitated by aquaglyceroporins in Prokaryota and Eukaryota. In holometabolan insects however, aquaglyceroporins are absent, yet several species possess polyol permeable aquaporins. It thus remains unknown how glycerol transport evolved in the Holometabola. By combining phylogenetic and functional studies, here we show that a more efficient form of glycerol transporter related to the water-selective channel AQP4 specifically evolved and multiplied in the insect lineage, resulting in the replacement of the ancestral branch of aquaglyceroporins in holometabolan insects. To recapitulate this evolutionary process, we generate specific mutants in distantly related insect aquaporins and human AQP4 and show that a single mutation in the selectivity filter converted a water-selective channel into a glycerol transporter at the root of the crown clade of hexapod insects. Integration of phanerozoic climate models suggests that these events were associated with the emergence of complete metamorphosis and the unparalleled radiation of insects. © 2015 Macmillan Publishers Limited. All rights reserved
Descripción7 pages, 4 figures, supplementary Information accompanies this paper at http://dx.doi.org/10.1038/ncomms8814
Versión del editorhttp://dx.doi.org/10.1038/ncomms8814
Identificadoresdoi: 10.1038/ncomms8814
e-issn: 2041-1723
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