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Using stem cells to produce insulin

AutorSoria Escoms, Bernat ; Gauthier, Benoit R.; Martín, Franz ; Bedoya Bergua, Francisco Javier ; Rojas, Anabel ; Hmadcha, Abdelkrim
Palabras claveβ-cell
Cell differentiation
Islet development
Pancreatic organogenesis
Pluripotent stem cells
Fecha de publicación9-jul-2015
EditorTaylor & Francis
CitaciónExpert Opinion on Biological Therapy 15(10): 1469-1489 (2015)
Resumen[Introduction]: Tremendous progress has been made in generating insulin-producing cells from pluripotent stem cells. The best outcome of the refined protocols became apparent in the first clinical trial announced by ViaCyte, based on the implantation of pancreatic progenitors that would further mature into functional insulin-producing cells inside the patients body. [Areas covered]: Several groups, including ours, have contributed to improve strategies to generate insulin-producing cells. Of note, the latest results have gained a substantial amount of interest as a method to create a potentially functional and limitless supply of β-cell to revert diabetes mellitus. This review analyzes the accomplishments that have taken place over the last few decades, summarizes the state-of-art methods for β-cell replacement therapies based on the differentiation of embryonic stem cells into glucose-responsive and insulin-producing cells in a dish and discusses alternative approaches to obtain new sources of insulin-producing cells. [Expert opinion]: Undoubtedly, recent events preface the beginning of a new era in diabetes therapy. However, in our opinion, a number of significant hurdles still stand in the way of clinical application. We believe that the combination of the private and public sectors will accelerate the process of obtaining the desired safe and functional β-cell surrogates.
Versión del editorhttp://dx.doi.org/10.1517/14712598.2015.1066330
Identificadoresdoi: 10.1517/14712598.2015.1066330
e-issn: 1744-7682
issn: 1471-2598
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