English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/123724
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

Intronic hammerhead ribozymes are ultraconserved in the human genome.

AutorPeña, Marcos de la ; García-Robles, Inmaculada
Palabras claveRibozyme, Intron, Splicing, Exaptation, Retrotransposons
Fecha de publicación23-jul-2010
CitaciónEMBO Reports
ResumenSmall ribozymes have been regarded as living fossils of a prebiotic RNA world that would have remained in the genomes of modern organisms. In this study, we report the ultraconserved occurrence of hammerhead ribozymes in Amniota genomes (reptiles, birds and mammals, including humans), similar to those described previously in amphibians and platyhelminth parasites. The ribozymes mapped to intronic regions of different genes, such as the tumour suppressor RECK in birds and mammals, a mammalian tumour antigen and the dystrobrevin beta in lizards and birds. In vitro characterization confirmed a high self‐cleavage activity, whereas analysis of RECK‐expressed sequence tags revealed fusion events between the in vivo self‐cleaved intron and U5 or U6 small nuclear RNA fragments. Together, these results suggest a conserved role for these ribozymes in messenger RNA biogenesis.
URIhttp://hdl.handle.net/10261/123724
Aparece en las colecciones: (IBMCP) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
711.full.pdf1,46 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


Este item está licenciado bajo una Licencia Creative Commons Creative Commons