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Title

Replication stress and cancer

AuthorsGaillard, Hélène ; García-Muse, Tatiana ; Aguilera, Andrés
Issue Date24-Apr-2015
PublisherNature Publishing Group
CitationNature Reviews Cancer 15: 276-289 (2015)
AbstractGenome instability is a hallmark of cancer, and DNA replication is the most vulnerable cellular process that can lead to it. Any condition leading to high levels of DNA damage will result in replication stress, which is a source of genome instability and a feature of pre-cancerous and cancerous cells. Therefore, understanding the molecular basis of replication stress is crucial to the understanding of tumorigenesis. Although a negative aspect of replication stress is its prominent role in tumorigenesis, a positive aspect is that it provides a potential target for cancer therapy. In this Review, we discuss the link between persistent replication stress and tumorigenesis, with the goal of shedding light on the mechanisms underlying the initiation of an oncogenic process, which should open up new possibilities for cancer diagnostics and treatment.
Publisher version (URL)http://dx.doi.org/10.1038/nrc3916
URIhttp://hdl.handle.net/10261/123721
DOI10.1038/nrc3916
Identifiersdoi: 10.1038/nrc3916
issn: 1474-175X
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