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Título

The evolution of viruses in multi-host fitness landscapes

AutorElena, Santiago F. ; Agudelo-Romero, Patricia ; Lalic, Jasna
Palabras clavevirus evolution
fitness landscapes
emerging viruses
multi-host pathogens
Fecha de publicación17-feb-2009
EditorBentham Science Publishers
CitaciónThe Open Virology Journal 3: 1-6
ResumenProvided that generalist viruses will have access to potentially unlimited hosts, the question is why most viruses specialize in few hosts. It has been suggested that selection should favor specialists because there are tradeoffs limiting the fitness of generalists in any of the alternative hosts or because evolution proceeds faster with narrower niches. Here we review experiments showing that virus adaptation to a specific host is often coupled with fitness losses in alternative ones. In most instances, mutations beneficial in one host are detrimental in another. This antagonistic pleiotropy should limit the range of adaptation and promote the evolution of specialization. However, when hosts fluctuate in time or space, selective pressures are different and generalist viruses may evolve as well.
Versión del editorhttp://www.bentham-open.org/pages/gen.php?file=1TOVJ.pdf&PHPSESSID=9d924a265ea7a14dba8f05ceb1e759ff
URIhttp://hdl.handle.net/10261/12364
DOI10.2174/1874357900903010001
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