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Non-coding RNAs in pluripotency and neural differentiation of human pluripotent stem cells

AutorLukovic, Dunja ; Moreno-Manzano, Victoria; Klabusay, Martin; Stojkovic, Miodrag; Bhattacharya, Shom Shanker ; Erceg, Slaven
Palabras clavePluripotent stem cells
Pluripotency
Non-coding RNA
Differentiation
Human embryonic stem cells
Fecha de publicación14-may-2014
EditorFrontiers Media
CitaciónFrontiers in Genetics 5: 132 (2014)
ResumenSeveral studies have demonstrated the important role of non-coding RNAs as regulators of posttranscriptional processes, including stem cells self-renewal and neural differentiation. Human embryonic stem cells (hESCs) and induced pluripotent stem cells (ihPSCs) show enormous potential in regenerative medicine due to their capacity to differentiate to virtually any type of cells of human body. Deciphering the role of non-coding RNAs in pluripotency, self-renewal and neural differentiation will reveal new molecular mechanisms involved in induction and maintenances of pluripotent state as well as triggering these cells toward clinically relevant cells for transplantation. In this brief review we will summarize recently published studies which reveal the role of non-coding RNAs in pluripotency and neural differentiation of hESCs and ihPSC
Versión del editorhttp://dx.doi.org/10.3389/fgene.2014.00132
URIhttp://hdl.handle.net/10261/123564
DOI10.3389/fgene.2014.00132
Identificadoresdoi: 10.3389/fgene.2014.00132
issn: 1664-8021
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