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A Low Noise Amplifier for Neural Spike Recording Interfaces

AuthorsRuiz-Amaya, Jesús; Rodríguez-Pérez, Alberto ; Delgado-Restituto, Manuel
KeywordsLow-Noise Amplifier
Neural spike recording
Biomedical circuit
Circuit sizing
Issue Date2015
PublisherMultidisciplinary Digital Publishing Institute
CitationSensors, 15: 25313-25335 (2015)
AbstractThis paper presents a Low Noise Amplifier (LNA) for neural spike recording applications. The proposed topology, based on a capacitive feedback network using a two-stage OTA, efficiently solves the triple trade-off between power, area and noise. Additionally, this work introduces a novel transistor-level synthesis methodology for LNAs tailored for the minimization of their noise efficiency factor under area and noise constraints. The proposed LNA has been implemented in a 130 nm CMOS technology and occupies 0.053 mm-sq. Experimental results show that the LNA offers a noise efficiency factor of 2.16 and an input referred noise of 3.8 Vrms for 1.2 V power supply. It provides a gain of 46 dB over a nominal bandwidth of 192 Hz–7.4 kHz and consumes 1.92 W. The performance of the proposed LNA has been validated through in vivo experiments with animal models
Publisher version (URL)http_//dx.doi.org/10.3390/s151025313
Appears in Collections:(IMSE-CNM) Artículos
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