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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/123197
Título

Gemin 5: a multitasking RNA-binding protein involved in translational control

AutorPiñeiro, David; Fernández-Chamorro, Javier; Francisco-Velilla, Rosario; Martínez-Salas, Encarnación
Palabras claveGemin5
RNA-binding proteins
Translation control
IRES elements
snRNPs
Picornavirus infection
Gemin5 proteolysis
Fecha de publicación17-abr-2015
EditorMultidisciplinary Digital Publishing Institute
CitaciónBiomolecules 5(2): 528-544 (2015)
ResumenGemin5 is a RNA-binding protein (RBP) that was first identified as a peripheral component of the survival of motor neurons (SMN) complex. This predominantly cytoplasmic protein recognises the small nuclear RNAs (snRNAs) through its WD repeat domains, allowing assembly of the SMN complex into small nuclear ribonucleoproteins (snRNPs). Additionally, the amino-terminal end of the protein has been reported to possess cap-binding capacity and to interact with the eukaryotic initiation factor 4E (eIF4E). Gemin5 was also shown to downregulate translation, to be a substrate of the picornavirus L protease and to interact with viral internal ribosome entry site (IRES) elements via a bipartite non-canonical RNA-binding site located at its carboxy-terminal end. These features link Gemin5 with translation control events. Thus, beyond its role in snRNPs biogenesis, Gemin5 appears to be a multitasking protein cooperating in various RNA-guided processes. In this review, we will summarise current knowledge of Gemin5 functions. We will discuss the involvement of the protein on translation control and propose a model to explain how the proteolysis fragments of this RBP in picornavirus-infected cells could modulate protein synthesis.
Descripción17 páginas; contiene gráficos y tablas
Versión del editorhttp://dx.doi.org/10.3390/biom5020528
URIhttp://hdl.handle.net/10261/123197
DOI10.3390/biom5020528
ISSN2218-273X
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