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Título

Inhibition of the Mitotic Exit Network in Response to Damaged Telomeres

AutorValerio-Santiago, Mauricio ; Santos-Velázquez, Ana Isabel; Monje-Casas, Fernando
Fecha de publicación10-oct-2013
EditorPublic Library of Science
CitaciónPLoS Genetics 9(10): e1003859 (2013)
ResumenWhen chromosomal DNA is damaged, progression through the cell cycle is halted to provide the cells with time to repair the genetic material before it is distributed between the mother and daughter cells. In Saccharomyces cerevisiae, this cell cycle arrest occurs at the G2/M transition. However, it is also necessary to restrain exit from mitosis by maintaining Bfa1-Bub2, the inhibitor of the Mitotic Exit Network (MEN), in an active state. While the role of Bfa1 and Bub2 in the inhibition of mitotic exit when the spindle is not properly aligned and the spindle position checkpoint is activated has been extensively studied, the mechanism by which these proteins prevent MEN function after DNA damage is still unclear. Here, we propose that the inhibition of the MEN is specifically required when telomeres are damaged but it is not necessary to face all types of chromosomal DNA damage, which is in agreement with previous data in mammals suggesting the existence of a putative telomere-specific DNA damage response that inhibits mitotic exit. Furthermore, we demonstrate that the mechanism of MEN inhibition when telomeres are damaged relies on the Rad53-dependent inhibition of Bfa1 phosphorylation by the Polo-like kinase Cdc5, establishing a new key role of this kinase in regulating cell cycle progression. © 2013 Valerio-Santiago et al.
Versión del editorhttp://dx.doi.org/10.1371/journal.pgen.1003859
URIhttp://hdl.handle.net/10261/123196
DOI10.1371/journal.pgen.1003859
Identificadoresdoi: 10.1371/journal.pgen.1003859
issn: 1553-7390
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