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Title

Thiourea-catalyzed addition of indoles to aliphatic β,γ-unsaturated α-ketoesters

AuthorsJuste-Navarro, Verónica; Marqués-López, Eugenia ; Herrera, Raquel P.
KeywordsAliphatic
Asymmetric organocatalysis
Indoles
Thioureas
β,γ-unsaturated α-ketoesters
Issue DateSep-2015
PublisherWiley-VCH
CitationAsian Journal of Organic Chemistry 4(9): 884–889 (2015)
AbstractA thiourea-catalyzed addition reaction with indoles to aliphatic β,γ-unsaturated α-ketoesters has been developed. The easily accessible thiourea aminoindanol derivative makes this approach an interesting alternative for the use of these aliphatic substrates, very scarcely employed in previously reported procedures, highlighting the complementarity of the strategy presented here. The final adducts, which are valuable intermediates for synthesizing the corresponding α-amino acid or α-hydroxy acid derivatives, are obtained in good yields and enantiomeric excess under mild reaction conditions.
DescriptionCommunication.
Publisher version (URL)http://dx.doi.org/10.1002/ajoc.201500154
URIhttp://hdl.handle.net/10261/123028
DOI10.1002/ajoc.201500154
ISSN2193-5807
E-ISSN2193-5815
Appears in Collections:(ISQCH) Artículos
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