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Título: | Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery |
Autor: | Méndez-Ardoy, Alejandro CSIC ORCID; Díaz Moscoso, Alejandro CSIC ORCID ; Ortiz-Mellet, Carmen; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M. CSIC ORCID CVN ; García Fernández, José Manuel CSIC ORCID | Fecha de publicación: | 2015 | Editor: | Royal Society of Chemistry (UK) | Citación: | RSC Advances, 5: 76464-76471 (2015) | Resumen: | Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling the efficacy of commercial vectors towards a variety of cell lines. Their molecular framework and modular design allow the installation of saccharidic antennae to promote specific carbohydrate-protein interactions, thus potentially endowing them with selective targeting abilities. Yet, the presence of these additional functionalities onto the polycationic cluster may hamper paCD self-assembly and nucleic acid condensation. In this report we describe the influence of paCD mannosylation extent on paCD-pDNA nanocomplex stability as well as the consequences of varying glycotope density on mannose-specific lectin recognition and gene delivery capabilites. The work aims at exploring the potential of this approach to optimize both properties in order to modulate cell transfection selectivity. | Versión del editor: | http://dx.doi.org/10.1039/C5RA16087A | URI: | http://hdl.handle.net/10261/123026 | DOI: | 10.1039/C5RA16087A |
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RSC Adv_mannosy-paCDs_final.docx | 3,79 MB | Microsoft Word XML | Visualizar/Abrir |
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