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Cerebrospinal fluid Presenilin-1: a potential new biomarker for Alzheimer’s disease

AuthorsSáez-Valero, Javier
Issue Date23-Jun-2014
CitationThe Alzheimer's Disease Congress (2014)
AbstractPresenilin-1 (PS1) is the active component of the γ-secretase complex, and its presence in cerebrospinal fluid (CSF) has not been measured to date. Recently we have demonstrated that PS1 is present in CSF as 100–150-kDa hetero-complexes containing both the N- and C-terminal fragments of the protein, as well other γ-secretase components, but differ from active γ-secretase membrane-complexes. Particularly, the levels of the highly stable PS1 complexes are increased in CSF samples from Alzheimer’s disease (AD) cases, suggesting potential value as a biomarker for AD. Estimation of PS1 CSF levels may be useful to challenge the disease-modifying effects of newer Alzheimer’s therapy
DescriptionCominicación a congreso presentada en The 2014 Alzheimer's Disease Congress: Biomarker Discovery and Assay Development, celebrado en Londres del 23 al 25 de junio de 2014
Appears in Collections:(IN) Comunicaciones congresos
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