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Generalized severe junctional epidermolysis bullosa with congenital absence of skin in churra lambs

AutorBenavides, Julio ; Suárez-Vega, Aroa; Gutiérrez, Jorge; de la Hera, S.; Fuertes, M. ; Delgado, L. ; Fernández, Mª del Carmen; Ferreras, Mª del Carmen ; Arranz, Juan José; Pérez Pérez, Valentín
Fecha de publicación2015
EditorBlackwell Publishing
CitaciónVeterinary Dermatology 26: 367- e83 (2015)
Resumen© 2015 ESVD & ACVD. Background: Up to 0.5% of churra lambs from two genetically related flocks showed congenital skin lesions of variable severity, jeopardizing the life of the lambs in the most severe cases. Hypothesis/Objectives: The primary objective of this study was to classify the type of congenital epithelial disease suffered by these animals, based on the description of the macroscopic skin defects, the histological and ultrastructural changes and the hereditary nature of the condition. Animals: Thirty affected newborn lambs from two genetically related flocks were studied. Three additional lambs acquired from two other flocks, which had no grossly apparent skin lesions and had died of infectious diseases, were studied as unaffected control animals. Methods: Histological and ultrastructural examinations of skin and oral mucosa samples were performed. Pedigree analyses were used to investigate genealogical relationships. Results: Generalized severe junctional epidermolysis bullosa with congenital absence of skin was described in all lambs studied and an autosomal recessive mode of inheritance was identified. Conclusions and clinical importance: The pathological findings and mode of inheritance in these lambs are similar to an inherited epidermolysis bullosa subtype of humans, which has not been reported previously in veterinary medicine.
Versión del editorhttp://dx.doi.org/10.1111/vde.12226
URIhttp://hdl.handle.net/10261/122957
DOI10.1111/vde.12226
ISSN1365-3164
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